Defining the extracellular matrix using proteomics
نویسندگان
چکیده
منابع مشابه
Using extracellular matrix proteomics to understand left ventricular remodeling.
Survival following myocardial infarction has improved substantially over the last 40 years; however, the incidence of subsequent congestive heart failure has increased dramatically as a consequence. Discovering plasma markers that signify adverse cardiac remodeling may allow high-risk patients to be recognized earlier and may provide an improved way to assess treatment efficacy. Alterations in ...
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Prolonged myocardial ischemia leads to myocyte necrosis, which initiates a localized inflammatory response that catabolizes the cellular debris and initiates deposition of extracellular matrix (ECM) proteins.1 In addition to providing a vital structural framework for the three-dimensional organization of cells, the ECM determines the physical properties of biological tissues and acts as a dynam...
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BACKGROUND The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS We performed a proteomics comparison of the vascular extracellular matrix an...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2013
ISSN: 0959-9673
DOI: 10.1111/iep.12011